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1.
the time or point when a plan or operation is executed. it comes from the military to describe when a plane lifts off to start a deployment, at that point an operation is considered hot (officially started).
We have to be packed and ready to go by 7:30 so we can be wheels up by 8.
por goopup 29 de Janeiro de 2006
 
2.
Originally stemmed from military jargon; means to depart from or leave an area or place, particularly via airplane.
I'm wheels up tomorrow.
por MrOklahoma 03 de Abril de 2011
 
3.
The phrase that fictional character Aaron Hotchner declares once choosing a case to investigate in the hit CBS show 'Criminal Minds'.

Once stating 'Wheels Up' the team go off to kick un-sub ass! Also, they always win.
'Aaron Hotchner take us back... WHEELS UP!'
por thecriminalprofiler 06 de Novembro de 2011
 
4.
After a wealthy, major sports figure is put out of contention he/she exits on their private plane
Tiger missed the cut at the U.S. Open and he was wheels up Friday afternoon
por ses-old 22 de Julho de 2006