1)Used by a (usually female) friend to encourage/praise another
2)Sarcastic expression used to mock one who is failing miserably at something/achieving something very insignificant
3)Expression used by camp gay males at any possible opportunity.
1) Janey: I just total betch-slapped that cow.
Joan: You Go, Girl!!
2)Janey threw an empty bottle into the bin from a distance of 10cm.
Crowd: YOU GO GIRL!
3)Dave: Want some coffee?
Mark: You go, girl!
Dave:....is that a yes?